Tirzepatide & Weight-Loss Clinics in South Dakota

A directory of 59 medical weight-loss and GLP-1 clinics across 20 South Dakota cities. Compare local in-person providers below — or skip the waitlist and get semaglutide from $197/month (tirzepatide from $397/month) online, medication and a licensed telehealth visit included, no insurance needed.

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Tirzepatide clinics in Sioux Falls, SD (3)

Sioux Falls Secret for Weight Loss★ 4.9 (35)
600 W 37th St Suite A, Sioux Falls, SD 57101
Encompass Wellness & Aesthetics★ 4.9 (418)
4301 W 57th St #160, Sioux Falls, SD 57101
Sanford Weight Management Center★ 5 (1)
3401 W 49th St, Sioux Falls, SD 57101

Tirzepatide clinics in Rapid City, SD (3)

Monument Health Weight Management - Rapid City
1136 Jackson Blvd, Rapid City, SD 57701
Monument Health Lifestyle Medicine★ 4.9 (33)
640 Flormann St, Rapid City, SD 57701
Gameday Men's Health Rapid City, SD★ 4.9 (121)
1301 W Omaha St Ste 224, Rapid City, SD 57701

Tirzepatide clinics in Brookings, SD (3)

Rooted Aesthetics & Wellness★ 5 (11)
426 3rd St Suite C, Brookings, SD 57006
Profile Plan - Personalized Weight Loss Plans (Virtual Location)★ 5 (101)
922 22nd Ave S, Brookings, SD 57006
Family Wellness Clinic★ 5 (52)
216 W Second St S, Brookings, SD 57006

Tirzepatide clinics in Watertown, SD (3)

Watertown Weight Loss Center★ 4.5 (2)
1024 29th St SE, Watertown, SD 57201
Novo Aesthetics★ 5 (6)
724 Stoney Pt Trl, Watertown, SD 57201
Weigh 2 Wellness★ 5 (1)
818 S Broadway Ste 102, Watertown, SD 57201

Tirzepatide clinics in Mitchell, SD (3)

Tailored To You Medical Aesthetics Clinic★ 4.9 (9)
1109 N Main St, Mitchell, SD 57301
Glow Aesthetics Med Spa★ 5 (8)
1012 Commerce St Suite 2, Mitchell, SD 57301, Mitchell, SD 57301
Ideal Weight Solutions
520 N Lawler St #200, Mitchell, SD 57301

Tirzepatide clinics in Yankton, SD (3)

Glow Aesthetics Med Spa★ 5 (45)
1101 Broadway Ave #103A, Yankton, SD 57078, Yankton, SD 57078
Abigail M Reynolds, MD★ 4.9 (191)
MD, 1104 W 8th St, Yankton, SD 57078, Yankton, SD 57078
Carrissa Pietz, MD★ 4.9 (184)
MD, 1104 W 8th St, Yankton, SD 57078, Yankton, SD 57078

Tirzepatide clinics in Huron, SD (3)

Luxe MedSpa★ 5 (40)
304 Kansas Ave SE Ste 1, Huron, SD 57350, Huron, SD 57350
Whole Weigh
857 Nebraska Ave SW, Huron, SD 57350
Forks Wellness & Medical Weight Loss★ 5 (19)
2015 Library Cir Ste A, Grand Forks, ND 58201, Huron, SD 57350

Tirzepatide clinics in Box Elder, SD (3)

Monument Health Weight Management - Rapid City
1136 Jackson Blvd, Rapid City, SD 57702, Box Elder, SD 57719
Monument Health Lifestyle Medicine★ 4.9 (33)
640 Flormann St, Rapid City, SD 57701, Box Elder, SD 57719
CoolCRYO Aesthetics & Wellness★ 4.9 (55)
4040 Cheyenne Boulevard Ste C, Rapid City, SD 57703, Box Elder, SD 57719

Tirzepatide clinics in Rapid Valley, SD (3)

Monument Health Lifestyle Medicine★ 4.9 (33)
640 Flormann St, Rapid City, SD 57701, Rapid Valley, SD
Gameday Men's Health Rapid City, SD★ 4.9 (121)
SD, 1301 W Omaha St Ste 224, Rapid City, SD 57701, Rapid Valley, SD
Peak Wellness - Personalized nutrition, activity and lifestyle coaching★ 4.9 (147)
activity and lifestyle coaching, 2050 W Main St Ste 1, Rapid City, SD 57702, Rapid Valley, SD

Tirzepatide clinics in Ellsworth Air Force Base, SD (3)

SD Weightloss Clinic by B MEDSPA★ 5 (2)
Weight Loss Department, 3033 Fifth Ave, San Diego, CA 92103, Ellsworth Air Force Base, SD
Ellsworth Medical Group★ 3.6 (38)
2900 Doolittle Dr, Ellsworth AFB, SD 57706, Ellsworth Air Force Base, SD
Weight Loss Center of San Diego (SD FAT LOSS)★ 4.9 (281)
1011 Camino del Rio S Suite 515, San Diego, CA 92108, Ellsworth Air Force Base, SD

Tirzepatide clinics in Madison, SD (3)

Revitalize Wellness & Med Spa★ 5 (13)
411 10th St SE Ste 102, Madison, SD 57042, Madison, SD 57042
UW Health East Madison Hospital Comprehensive Medical and Surgical Weight Management Program★ 4.9 (67)
4602 Eastpark Blvd, Madison, WI 53718, Madison, SD 57042
Vibrance Aesthetics★ 5 (5)
103 Egan Ave S, Madison, SD 57042, Madison, SD 57042

Tirzepatide clinics in Sturgis, SD (2)

Remedy 605★ 4.9 (63)
Remedy 605, Sturgis, SD 57785
Monument Health Sturgis Clinic★ 4.8 (1200)
2140 Junction Ave, Sturgis, SD 57785

Tirzepatide clinics in Belle Fourche, SD (3)

RevIVe Medical★ 5 (4)
611 Dahl Rd Ste 9, Spearfish, SD 57783, Belle Fourche, SD 57717
Monument Health Belle Fourche Clinic★ 4.8 (575)
2200 13th Ave, Belle Fourche, SD 57717
Monument Health Metabolic and Bariatric Institute★ 5 (28)
1445 North Ave, Spearfish, SD 57783, Belle Fourche, SD 57717

Tirzepatide clinics in Harrisburg, SD (3)

Jatto Internal Medicine & Wellness★ 4.6 (133)
2205 Forest Hills Dr #12, Harrisburg, PA 17112, Harrisburg, SD 57032
Vitalis MVMT + Wellness★ 5 (37)
220 S Cliff Ave Ste 126, Harrisburg, SD 57032, Harrisburg, SD 57032
Thermal Burn16 - Weight Loss Supplements
27298 Wetland Rd Suite #102, Harrisburg, SD 57032, Harrisburg, SD 57032

Tirzepatide clinics in Hot Springs, SD (3)

Monument Health Hot Springs Clinic★ 4.9 (302)
1100 State Hwy 71 #101, Hot Springs, SD 57747, Hot Springs, SD 57747
CHI St. Vincent Weight Loss Clinic-Hot Springs
1 Mercy Ln #201, Hot Springs, AR 71913, Hot Springs, SD 57747
Hot Springs VA Medical Center★ 4 (35)
500 N 5th St, Hot Springs, SD 57747, Hot Springs, SD 57747

Tirzepatide clinics in Mobridge, SD (3)

Mobridge Regional Hospital and Clinics★ 3.5 (28)
1401 10th Ave W, Mobridge, SD 57601
Vitalis MVMT + Wellness★ 5 (37)
220 S Cliff Ave Ste 126, Harrisburg, SD 57032, Mobridge, SD 57601
Mobridge Medical Clinic★ 3 (4)
1309 10th Ave W, Mobridge, SD 57601

Tirzepatide clinics in Pine Ridge, SD (3)

Revive Health Medical Weight Loss & Wellness★ 5 (48)
10627 165th St W, Lakeville, MN 55044, Pine Ridge, SD 57770
Vitalis MVMT + Wellness★ 5 (37)
220 S Cliff Ave Ste 126, Harrisburg, SD 57032, Pine Ridge, SD 57770
Conklin Clinics★ 4.8 (152)
2120 8th Ave NE, Aberdeen, SD 57401, Pine Ridge, SD 57770

Tirzepatide clinics in Lead, SD (3)

Monument Health Metabolic and Bariatric Institute★ 5 (28)
1445 North Ave, Spearfish, SD 57783, Lead, SD 57754
Monument Health Lifestyle Medicine★ 4.9 (33)
640 Flormann St, Rapid City, SD 57701, Lead, SD 57754
Monument Health Weight Management - Spearfish
930 N 10th St, Spearfish, SD 57783, Lead, SD 57754

Tirzepatide clinics in North Sioux City, SD (3)

Vibrance Medical, PLLC★ 5 (16)
PLLC, 101 Tower Rd #103, Dakota Dunes, SD 57049, North Sioux City, SD 57049
Encompass Wellness & Aesthetics★ 5 (17)
319 Dakota Dunes Blvd Ste. B, North Sioux City, SD 57049
Metabolic Research Center | Sioux City★ 5 (20)
4700 Gordon Dr Ste 101, Sioux City, IA 51106, North Sioux City, SD 57049

Tirzepatide clinics in Dakota Dunes, SD (3)

CNOS Sioux Point Clinic★ 3.7 (36)
705 Sioux Point Rd #100, Dakota Dunes, SD
Vibrance Medical, PLLC★ 5 (16)
101 Tower Rd #103, Dakota Dunes, SD
Gameday Men's Health Dakota Dunes, SD★ 5 (121)
895 Cottonwood Ln Ste. B, Dakota Dunes, SD

Disclaimer: Clinic listings sourced from public business directories. Not medical advice or an endorsement. Verify credentials independently. Pricing for online GLP-1 (DirectMeds): semaglutide $197 first month then $297/mo, tirzepatide $397 first month then $497/mo; medication and telemedicine visit included. Results vary; consult a licensed clinician.